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Of potential clinical significance is that the leptin-like effects of FGF19 on glucose homeostasis and insulin sensitivity are effective even in the DIO mouse where leptin effects are lost

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For instance, quantitative flux analysis of NADPH, which employs tracking of deuterium incorporation into NADPH, has revealed that folate-dependent methylenetetrahydrofolate dehydrogenase (MTHFD)-mediated NADPH production provides anti-oxidant activity to cells and enables resistance to oxidative stress (68)